Contents

​This study evaluated the 5-year oncologic outcomes of patients with apparent early-stage high-intermediate and high-risk endometrial cancer who underwent either sentinel node mapping or systematic lymphadenectomy. Involving 242 patients, the research aimed to compare survival outcomes between these two groups using a multi-institutional retrospective, propensity-matched approach. The analysis included 73 patients who underwent hysterectomy plus sentinel node mapping, with a successful bilateral mapping rate of 91.7%. Sentinel nodes were detected in the para-aortic area in 10.9% of cases, and 32.8% of patients were diagnosed with nodal disease. Through propensity-score matching, 70 patient pairs (sentinel node mapping vs. lymphadenectomy) were compared, revealing no significant difference in 5-year disease-free survival and 5-year overall survival between the two groups. The findings suggest that sentinel node mapping does not negatively impact the 5-year outcomes of patients with high-intermediate and high-risk endometrial cancer, advocating for further prospective studies to validate these results. 

Citation

Eur J Surg Oncol. 2024 Feb 15;50(4):108018.

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Link

https://www.sciencedirect.com/science/article/pii/S0748798324000702?via%3Dihub